This article is for Medical Students & Professionals
This is a Question & Answer revision article designed for medical students and professionals preparing for the PLAB, MRCP or USMLE examinations. They are based on actual questions from these examinations. You may find the Hepatitis B article more useful, or one of our many articles on Diseases & Conditions, Medical Syndromes, Health & Wellness or Home Remedies.
Vaccination for HBV prevention
MCQ: clinical scenario
MCQ: answer
MCQ: explanation
Vaccination for HBV prevention
Hepatitis B virus (HBV) infection can potentially be eradicated through global vaccination. Globally, vaccine coverage for infants based upon completion of the third dose of vaccine (HepB3) has increased from 3 percent in 1992 to 84 percent in 2015. However, even in countries that actively advocate universal vaccination, coverage is less than 100 percent. As an example, the vaccine coverage in Taiwan for birth cohorts from 1984 to 2010 was 88.8 to 96.9 percent.MCQ: clinical scenario
You are asked to ensure that all your hemodialysis staff have appropriate prophylaxis against hepatitis B. One of the workers is not immunised.Which agent would offer most appropriate prophylaxis?
a) recombinant hepatitis B vaccine
b) hepatitis B e antigen
c) Hepatitis B surface antigen
d) hepatitis C vaccine
e) hepatitis B immune globulin (HBIG)
MCQ: answer
The correct answer is AMCQ: explanation
Active immunization has become possible with the advent of hepatitis B vaccine. The original vaccine was prepared from the plasma of hepatitis B carriers. Although this vaccine underwent multistep inactivation that destroyed the infectivity of all known viruses (including HIV), concerns over the origin of the vaccine from high-risk persons limited its acceptance. In 1987, a recombinant vaccine became available, derived from recombinant yeast into which the gene for surface antigen had been inserted. Such vaccines have replaced plasma-derived vaccines.Reference(s)
1). UpToDate: Hepatitis B virus immunization in adults. Available online: https://www.uptodate.com/contents/hepatitis-b-virus-immunization-in-adults
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